Micronization of Levofloxacin by RESS Method
Abstract
Исследована микронизация антибактериального препарата левофлоксацина методом RESS с целью получения микрочастиц, обладающих высокой биологической доступностью. Для увеличения растворимости левофлоксацина в сверхкритическом диоксиде углерода быш использован этанол в качестве сорастворителя. Получены микрочастицы левофлоксацина сферической формы с характерными размерами менее 10 мкм. Micronization of anti-bacterial drug levofloxacin (LF) by the RESS method for obtaining microparticles with high bioavailability was performed. Ethanol was used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with characteristic sizes < 10 microns were obtained.
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