Characterization of Wound Dressing with Microspheres Containing Levofloxacin
Abstract
A novel functional material was prepared by composing chitosan-levofloxacin complex microspheres with viscose nonwoven fabrics. The complex microspheres were made by ionic and emulsion crosslinking method. The mor- phology and formulation of the material were investigated by SEM,FTIR and DSC. The drug release property in vitro was evaluated by UV. The cytotoxicity and its antibacterial property were tested by L929 fibroblast culture and the spread plate method respectively. The results showed that the microspheres were embedded in the fabrics, chitosan mi- crospheres were formed by Schiff base reaction and there are no chemical crosslinking appearance between viscose fibers and chitosan-levofloxacin complex microspheres. Levofloxacin could release slowly and its sustained release property can be controlled by the concentration of chitosan solution effectively. In addition, there were no obvious toxicity role presented and its antibacterial action was excellent. The functional material has the potential to be used as levofloxacin sustained releasing wound dressing.
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