Comparative-Study of Levofloxacin Solubility in Supercritical Carbon Dioxide and Trifluoromethane
Abstract
Abstract The solubility of levofloxacin (LFC) in supercritical carbon dioxide and trifluoromethane has been measured within the pressure range of 10–30 MPa at temperatures of 323 and 373 K. The solubility was determined by changes in the mass of the LFC sample kept in an SC fluid at the given temperature and pressure. The obtained value of LFC solubility in supercritical trifluoromethane at a pressure of 30 MPa and temperature of 323 K is almost an order of magnitude higher than its solubility in supercritical carbon dioxide under the same conditions: (5.6 ± 0.3) × 10–5 mole fractions compared to (5.9 ± 0.3) × 10–6 mol fractions. At the pressure of 30 MPa and temperature of 373 K, the LFC solubility in supercritical trifluoromethane reaches a value of (8.3 ± 0.3) × 10–5 mol fractions. The obtained results are the basis for further development and optimization of SCF-micronization processes of various antibiotics of the fluoroquinolone group without a liquid cosolvent.
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