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A systematic review of symmetrical drug-related intertriginous and flexural exanthema

Eunheh Koh, Joo Young Jung, Michelle Lin, Ahmad Rathor, Loretta S. Davis

JAAD reviews., 2025

1 citation

Abstract

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a T-cell mediated, benign drug reaction that presents as a bilateral intertriginous rash.1 This review summarizes the reported causative medications, clinical presentations, and management for SDRIFE.

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Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.

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