Silver nano-particulate coating on implantable titanium devices: CAN WE teach an OLD DOG a NEW trick? —A systematic review
Abstract
Implant materials are one of the most investigated topics in modern medicine. This review is focused only on addressing silver as coating substance on top of titanium based implantable devices, and focused on the last five years of silver coated titanium implants on human cell population. This study was conducted on Medline, PubMed, Science Direct, Scopus and Google Scholar. A time window of the previous five years was selected up to May of 2021. The study was done at HBS Dental College, Islamabad and the Higher Education Commission Library, Islamabad. The multi-location reviewing and gathering of articles assured lack of bias in the article selection. The search for articles was done using prescribed keywords and then the sieving of articles further using systemic review methodology via PRISMA flowchart. There was excessive evidence to suggest that the surface modification with silver is effective to eliminate surface microbes which might interfere in good quality healing of bone around the titanium implant material. Silver has great antimicrobial activity however it does not show simultaneously just as good compatibility. This study points towards evidence of establishing the ‘sweet spot’ between the most favourable cytotoxic concentrations and most effective antimicrobial concentrations. Pak J Pysiol 2023;19(3):51–5
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Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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