Combination Therapies and Multi-Drug Delivery Systems
Abstract
Combination therapy is a progressing strategy that employs multiple therapeutic agents simultaneously to treat complex diseases like cancer, diabetes, and bone/tissue regeneration. The main goal is to enhance therapeutic efficacy by improving the release profile, reducing drug resistance, and minimizing toxic effects through the invasion of multimechanistic pathways. Conversely, the concurrent delivery of multiple drugs poses significant challenges, particularly when controlled and spatial delivery is required. To augment these issues, Multi-Drug Delivery Systems (MDDS) with advanced techniques have been developed. Electrospinning and electrospraying emerged as promising solutions for the development of MDDS (liposomes, microspheres, core-shell nanoparticles, nanofibers, and scaffolds). The fabricated delivery systems offer scrupulous control over release pattern, timing, dosage, and duration of each drug. These advanced carrier systems can contain both hydrophilic and hydrophobic drugs by developing multilayered fibers or particles. Electrospun and electrosprayed delivery systems can address drug resistance, heterogeneous micro-environments, and dose-limiting toxicity by providing control over drug distribution and release. Moreover, integrating these advanced approaches into MDDS offers a resourceful platform in the field of drug delivery. These systems provide an efficient avenue to enhance the effectiveness of existing drugs rather than developing new ones, for advancing…
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