Innovative hydrogel-based wearable devices for healthcare applications
Abstract
This dissertation presents the development of advanced hydrogel-based platforms, enhanced with functional nanomaterials, for next-generation healthcare monitoring and biomedical applications. Leveraging the inherent biocompatibility, high water content, and three-dimensional polymer structure of hydrogels, this work integrates sensing and therapeutic components to create multifunctional devices. The research is structured into two complementary parts. Part I introduces a sustainable, colorimetric sensor for the non-invasive detection of prostate cancer. The hydrogel matrix was fabricated from recycled office wastepaper, using polyvinyl alcohol (PVA) as a gelling agent and carboxymethyl cellulose (CMC) to enhance structural integrity. The incorporation of graphene oxide (GO) as a nanomaterial support for the NQS reagent enabled the sensitive, colorimetric detection of sarcosine—a key urinary biomarker for prostate cancer. The resulting sensor provides a visual color change directly correlated with sarcosine concentration, facilitating simple and continuous monitoring. Part II details the creation of a smart, 3D-printed theranostic pad for managing wound infections. Fabricated via a dual-nozzle printing technique, this single-construct device combines diagnostic and therapeutic capabilities. The printed hydrogel exhibits a porous structure ideal for high fluid absorption and controlled drug release. It incorporates bromocresol purple (BCP) as a pH-responsive dye, which…
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.