Novel chemical and physical approaches for sustainable drug release from biodegradable electrospun nanofibres
Abstract
Drug delivery systems have great importance for medical application. There have been wide ranging studies on drug delivery systems up to date. Among them, the fabrication of nano-size drug delivery systems and utilizing them for the effective and controlled delivery of drugs is an emerging and promising field of research. Various studies on drug nanocarriers have been reported such as electrospun nanofibres and nanoparticles; however the main drawback of nearly all is that they lack the control over the release profile of the drug. The burst release of drug is the main issue reported seen in almost all cases. The purpose of this work was to develop composite biodegradable nanofibres fabricated using the electrospinning technique with different chemical and physical approaches to slow down the fast burst release and control the release profile. This thesis exploits electrospun biodegradable nanofibres as the main carrier of drug/nanoparticles complexes and drug-conjugated polymers to obtain sustained release of drug. To achieve this, mesoporous silica nanoparticles (MSN) acting as a nano sized vehicle as a drug delivery system were first investigated. Then, the adsorption of the drug into mesoporous structure was fabricated and characterized. The drug loaded nanoparticles were confined to the core section of core-shell nanofibres by means of co-axial electrospinning. This method provided a reduction in burst release compared to regular drugnanofibres and a sustained release.…
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