Biomedical applications of hybrid polymer-based materials
Abstract
Polymers have been widely used in biomedical applications for drug delivery purposes in the last decades. However, ordinary long term drug delivery systems are sometimes associated with undesired side effects if the concentration of the released drug is higher than needed. Therefore scientists look for new techniques to enhance the efficiency and safety of the release by controlling the release time. ra_teand accuracy in targeting specific tissues or cells to spare the rest of the body from side effects. In this thesis. several polymeric platforms (microfibers, hydrogels, nanoparticles, nanomembranes) and their combinations have been used to modulate and control the release of different kinds of drugs. Five different platforms have been obtained. They are described in the results section of the thesis (chapter 3): 1) In section 3.1, an electrically triggered release system is presented. Specifically, the release of the antibiotic chloramphenicol (CAM) from conducting polymer nanoparticles made of poly(3,4-ethylenedioxythiophene (PEDOT) has been studied and characterized. In addition, the designed platform allows for in situ monitoring of bacteria! growth inhibition through the electrochemical detection of 13-nicotinamide adenine dinucleotide (NADH). 2) A pharmacological chaperorie (pyrimethamine, PYR) has been also encapsulated in PEDOT nanoparticles (section 3.2). Release experiments carried out with and without electrical stimuli demonstrate that release can be increased…
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