Development and characterization of novel SUB-coatings with polymorphic brookite titania nanoparticles: enhanced UV/VIS photocatalytic antibacterial and anticancer properties
Abstract
ABSTRACT Nosocomial and community infections and biofilm formation from bacteria has increased significantly through adaptation combined with overuse of broad spectrum antibiotics. Because the world population continues to escalate, hospitals and long-term managed care will also escalate, thereby increasing transmission of infections, lowering patients' quality of health. Another disease on the rise throughout the world is skin cancer. A treatment modality that would cause less deleterious effects on the patient would be ideal. These two seemingly different issues could be solved with one product. First an inexpensive, safe, and non-selective antimicrobial surface coating would enhance the hospital arena and a coating that would treat skin cancer like wearing a band-aid would be patient friendly. We proposed two novel sub-coatings containing polymorphic Titanium dioxide, Br200 and BrNMP. Titanium dioxide is versatile, non-selective, and degrades compounds through photocatalytic oxidation. The antibacterial sub-coating made of Poly(diallyldimethylammonium chloride) solution (PDDA) and Poly(4-styrenesulfonic acid) solution (PSS) in a 1:1 ratio of 0.1M PDDA/PSS as a 25 layer-by-layer coating on glass cover slips is known as the P sub-coating. It contains Nitrogen and Sulfur molecules that were associated via low temperature liquid deposition with Br200 or BrNMP Titania. XRD and XPS evaluations of these P sub-coatings containing the polymorphic Br200 and BrNMP confirmed a match…
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