Interaction of liposomal forms of levofloxacin with pulmonary surfactant
Abstract
The interaction between liposomal levofloxacin and bovine pulmonary surfactant was investigated. It has been demonstrated using Langmuir-Wilhelmy techniques, AFM, IR and fluorescence microscopy that functionalizing the surface of liposomes with mannosylated chitosan minimizes the initial fusion of vesicles with surfactant, while also assisting in the retention of the formulation at the surfactant-air interface.
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