Comparison of Drug Resistance of Moxifloxacin and Levofloxacin in Mycobacterium tuberculosis Strains
Abstract
Mahdi Shamsi, Parissa Farnia, Ali Akbar Velayati Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Objective: Drug-resistant tuberculosis is a chronic respiratory infectious disease. Fluoroquinolone drugs have a broad spectrum of antibacterial activity and are particularly useful in treating diseases caused by Mycobacterium tuberculosis and can lead to bacterial death. This study focuses on examining and comparing the clinical effects of fluoroquinolone drugs: levofloxacin and moxifloxacin in the treatment of multidrug-resistant tuberculosis (MDR-TB). Methods: This descriptive study was carried out in 2023 on samples sent to the National Tuberculosis Reference Laboratory. These samples include sputum and other fluids isolated from the bodies of patients suspected of tuberculosis. Initial experiments such as culture on Lowenstein–Jensen medium and direct smear observation were performed. Using the proportional method, 133 samples were tested for sensitivity against first-line drugs, levofloxacin, and moxifloxacin. Results: Out of the 133 clinical isolates studied, 81 patients were male and 52 patients were female. Age analysis showed that these patients ranged from 15 to 90 years old with an average age of 52.5 years. The results of drug sensitivity testing on the 133 clinical isolates of M. tuberculosis indicate that 103 individuals (77.9%) were resistant…
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