Synthesis, Characterization, and Investigation of Antimicrobial Properties of Salt and Metal Complexes of 2,6-Pyridinedicarboxylic Acid and 2-Amino-4,6-dimethylpyridine
Abstract
A new salt (3) of 2,6-pyridinedicarboxylic acid (1) and 2-amino-4,6-dimethylpyridine (2) and the metal complexes of the salt {(H2)x[M(1)2].nH2O, M = Fe (III), x = 1, n = 3 (4); M = Co(II), x = 2, n = 4 (5); M = Ni(II), x = 2, n = 5 (6); M = Cu(II), x = 2, n = 4 (7)} were synthesized. The structures of the compounds were suggested by AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans (ATCC 14053) (yeast), Pseudomonas. aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL-B 767), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Enterococcus faecalis (ATCC 29212), and Escherichia coli (ATCC 25922) bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3 in B. subtilis bacteria, 6 and 7 in S. aureus bacteria, 5 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds (except 4) in E. coli bacteria, 2 in E. faecalis bacteria and 4 in C. albicans yeast.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.