S1381 Statins and the Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases: A Systemic Review and Meta-Analysis
Abstract
. Introduction: In fl ammatoryboweldisease(IBD),encompassingCrohn ’ sdisease,ulcerativecolitis,andmicroscopiccolitis,isfrequentlylinkedtonutritionalimpairments,includingprotein-energymalnutrition (PEM). These nutritional de fi cits often contribute to adverse clinical outcomes. This study aims to investigate the impacts of malnutrition on the cardiovascular outcomes of patients hospitalized with IBD. Methods: The National Inpatient Sample database from 2017 to 2020 was used to identify hospitalized patients with IBD, using relevant ICD-10 codes; inclusion criteria included adult patients. The patients werestrati fi edinto2groupsbasedonthepresenceofmalnutrition(protein-energy).Theprimaryoutcomewasin-hospitalmortality.Secondaryoutcomeswerelengthofstay(LOS),totalhospitalcharges(THC), development of atrial tachyarrhythmias ( fi brillation/ fl utter), ventricular tachyarrhythmias (tachycardia/ fi brillation), bradyarrhythmias, bundle blocks, cardiac arrest, acute venous thrombotic events, and acute pulmonary embolism. Multivariable regression analyses (accounting for patient and hospital characteristics) were performed. Results: Thestudypopulationcomprised72,009patientswithIBD,ofwhich10,744(14.92%)hadconcomitantmalnutrition.Onmultivariateanalysis,thepresenceofmalnutritionwasassociatedwithincreased odds of in-hospital mortality (adjusted odds ratio [aOR] 1.
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