ACTIVATE: A pilot randomized activity coaching trial to increase vitality and energy during post-operative pelvic radiation therapy for endometrial cancer
Abstract
TPS12147
Background:
The ASCO-Society for Integrative Oncology guidelines strongly recommend exercise as a therapeutic strategy for cancer-related fatigue (CRF), advising that exercise regimens be tailored to each patient’s capabilities. Despite this broad endorsement, at least two-thirds of cancer patients are unable to adhere to the recommendation of exercise due to symptoms and barriers, with women being more likely than men to report barriers to adherence to exercise. There is a lack of data on how to effectively integrate exercise into the treatment regimens of pelvic radiation therapy (RT). Most studies focus on other cancer types or male patients, leaving a significant gap in the literature regarding female patients with gynecological malignancies. Given the high prevalence of CRF and its impact on QoL, interventions reducing fatigue are vital. The primary objective of the ACTIVATE pilot trial(NCT06746428)is to evaluate the feasibility and acceptability of conducting a randomized trial with an exercise coaching program as the intervention in this patient population. Secondary objectives include estimating preliminary efficacy of exercise coaching on fatigue and health-related quality of life, quantifying baseline fatigue levels in our patient population, assessing eligibility criteria suitability, and exploring behavioral mechanisms and variables influencing intervention strength.
Methods:
The study methods include randomization of immediate versus delayed…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 16 participants or records.
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