Effects of sevoflurane and propofol on hemodynamics during cardiac surgery: A randomized controlled clinical trial
Abstract
The anaesthetic support for various types of cardiac surgery such as coronary artery bypass grafting, heart valve repair or replacement is essential for success of a surgery. The planning of anaesthesia depends on the intended surgical procedure. The traditional approach is total intravenous anesthesia with propofol and inhalation with sevoflurane.
Objectives: To identify the advantages and disadvantages of propofol and sevoflurane when cardiac surgery in adults.
Material and methods: A total of 40 patients were assigned randomly into two groups to receive: in Group 1 - propofol and in Group 2 - sevoflurane. The induction to general anesthesia started with intravenous fractional administration of 1-1.5 mg/kg propofol, 5-7 µg/kg fentanyl and 1.5-2 mg/kg ketamine. Pipecuronium bromide 0.07-0.1 mg/kg was used as a myorelaxant in all patients in both groups. The anaesthesia in group P was supported with propofol 4-6 mg/kg/min intravenously by means of a perfusor as anaesthetic. In group 2, sevoflurane at a dose of 1.7-1.9 MAC was used as an anaesthetic. To maintain anaesthesia in both groups, there was a fractional administration of fentanyl at a dose of 100 µg intravenously when the heart rate and blood pressure increase, piperonium bromide in a dose of 2 mg intravenously was used for muscle relaxation.
Results: The mean arterial pressure, oxygen demand, energy expenditure, cardiac index, total peripheral resistance showed statistically significant differences between propofol…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 40 participants or records.
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