A meta-analysis: dietary carbohydrates do not increase body fat or fasted insulin and glucose in cats
Abstract
Abstract Commercial cat foods contain a greater carbohydrate content, such as nitrogen-free extract (NFE), compared to a typical prey species. This has led to postulations that increased carbohydrate intake is causing a rise in obesity and IR in cats. Studies investigating high-carbohydrate diets on insulin and glucose responses show inconsistent results. A meta-analysis using 16 studies was conducted to elucidate the relationship between NFE content and body fat mass (BFM, n = 9), fasted insulin (n = 12), and fasted glucose concentrations (n = 14). Dietary NFE, fat, and protein content (% metabolizable energy), as well as daily energy intake (DEI), body weight, body condition (lean, obese), and study design metrics were considered as fixed effects in univariate and multivariate models using proc mixed in SAS, treating study as a random effect. Model evaluation was conducted using corrected Akaike Information Criteria, concordance correlation coefficient, and the root mean square prediction error. The best-fitting model for BFM was the interaction between NFE content and DEI, predicting BFM to decrease when NFE content increased as a proportion of the DEI (P 0.05). The results of this meta-analysis indicate that dietary carbohydrates (NFE), included between 2.8% and 57% ME, are not a risk factor for greater BFM, fasted insulin, and glucose concentrations in cats, suggesting that NFE does not pose a risk for feline obesity, IR, or hyperglycemia. However, future studies should…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 14 participants or records.
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