Seroprevalence of brucellosis in humans and livestock in Sub-Saharan Africa: a systematic review and meta-analysis
Abstract
Brucellosis is a neglected tropical zoonotic disease of public health and economic concern. The disease is maintained within the populations by infected animals, and humans get infected via the consumption of livestock products and contact with post-parturient materials from an infected animal. Understanding the extent and distribution of the disease in both humans and animals is necessary for effective prevention and control in Sub-Saharan Africa (SSA). Therefore, this systematic review and meta-analysis aimed to determine the seroprevalence of brucellosis in humans and domestic livestock in SSA. The review protocol was registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY) under registration number: INPLASY2023120123. A comprehensive search was done in six databases: PubMed, OpenAlex, Google Scholar, Semantic Scholar, and Cross-ref, utilizing Medical Subject Headings (MESH). A number of keywords relevant to the subject of study were used to search through the selected online databases for articles published between 01 January 2012 and December 2024. Two hundred forty two full-text articles that fulfilled the eligibility criteria, distributed across 25 countries in SSA, were included in the final analysis. Cross-sectional studies that reported seroprevalence estimates on brucellosis infection for humans and domestic livestock species were included, whereas studies that reported seroprevalence estimates involving…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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