Effectiveness of Combination Therapy of Bone Marrow-Derived Mesenchymal Stem Cell for Enhancing Potential Therapeutic Effect on Ankle Arthritis: A Systematic Review
Abstract
Background and Objectives: Current treatment options for ankle arthritis often provide only short-term therapeutic benefits, with frequent recurrence of symptoms. In recent years, various stem cell based therapies have been developed due to their regenerative potential and ability to promote tissue repair in ankle arthritis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent one such therapeutic approach, isolated from bone marrow and expanded in vitro, offering notable anti-inflammatory and osteoregenerative properties. The combination of BM-MSC therapy with existing treatment modalities is anticipated to enhance overall therapeutic efficacy.
Methods: This systematic review aims to evaluate the potential therapeutic effects of combining bone marrow-derived mesenchymal stem cell (BM-MSC) with existing treatment modalities. Comprehensive literature search was conducted using databases including PubMed, ResearchGate, Google Scholar, and ScienceDirect. Eligible studies included animal models, interventional and descriptive research, as well as other analytical and observational study designs.
Results: Five studies met the eligibility criteria and were included in the review. These studies utilized BM-MSC that had been isolated and cultured from bone marrow tissue. The experimental models involved rats in which arthritis had been experimentally induced. Overall, the combination of BM-MSCs with various therapeutic interventions demonstrated enhanced therapeutic…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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