A case of pyogenic spondylitis caused by mesh infection after laparoscopic sacrocolpopexy
Abstract
We report a case involving an 81-year-old woman who developed pyogenic spondylitis following laparoscopic sacrocolpopexy (LSC) for a cystocele in November year X. During concomitant uterine resection, purulent discharge was observed, and oral levofloxacin was administered for 5 days postoperatively. Pathological examination revealed xanthogranulomatous endometritis, which was considered the source of the mesh infection. The patient was discharged on postoperative day 7 without complications. In early January year X＋1, she developed buttock pain that persisted for approximately 2 weeks without improvement, prompting her to return to our hospital. Magnetic resonance imaging findings indicated pyogenic spondylitis. She was admitted and treated with intravenous sulbactam/ampicillin for 1 week, but her symptoms did not improve. Laparoscopic mesh removal was subsequently performed. After surgery, the antibiotic regimen was switched to intravenous imipenem/cilastatin, resulting in good infection control. However, progressive bone destruction was noted, and on postoperative day 37, posterior spinal fusion from L3 to the pelvis was performed by our orthopedic team. The postoperative course following spinal surgery was favorable, with marked symptom relief. Oral minocycline was initiated on postoperative day 69 and continued until day 133. The patient was discharged ambulatorily on postoperative day 139. Although pyogenic spondylitis is recognized as a serious complication of LSC,…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.