The Differentiation of Soft Tissue Infiltration and Surrounding Edema in an Animal Model of Malignant Bone Tumor: Evaluation by Dual-Energy CT
Abstract
To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft tissues were divided into 3 areas according to pathology and computed tomography images. Computed tomography spectral curve slopes and iodine and water concentrations were assessed. Statistical analyses were performed using the Mann-Whitney U test and t test. The spectral curve of the soft tissue infiltration areas has a slope (1.30 ± 0.41) higher than that of the soft tissue edema areas (0.71 ± 0.23; P < .001). The iodine concentration in the soft tissue infiltration areas (8.56 ± 2.15) was higher than that in the in soft tissue edema areas (6.09 ± 1.02; P < .001). Water concentration was similar in the soft tissue infiltration areas (1033.86 ± 10.50) to that of the edema areas (1031.45 ± 12.83; P < .05). Spectral curve analysis and iodine–water concentration are helpful in the differentiation of bone tumor soft tissue infiltration and soft tissue edema.
Read the paper
Related studies
- Chaos and quantum thermalization
- The Dalton quantum chemistry program system
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study
- Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
- Stable adiabatic quantum batteries
- A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.