Diagnostic Optical Imaging of Breast Cancer: From Animal Models to First-in-Men Studies
Abstract
The use of light-driven imaging techniques for the diagnosis of breast cancer dates back to as early as 1929. Transillumination was evaluated for potential differentiation of breast lesions, e.g. to distinguish benign cysts from solid tumours. Cutler summed the technique to be “...a simple procedure and a valuable aid in the interpretation of pathological conditions in the mammary gland. Its use is recommended in the routine examination of the breast...”(Cutler, 1929, 1931).
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