Quantum Chemical, Spectroscopic and In Silico (Molecular Docking, Molecular Dynamic and ADME ) Studies on Anti‐Aging Pentapeptide‐3 (Vialox)
Abstract
ABSTRACT Skin aging is accelerated by environmental factors such as long‐term UV exposure, stress, smoking, alcohol consumption, and a poor diet. This process primarily results from the build up of oxidative stress caused by reactive oxygen species (ROS). Pollutants, toxins, and excessive exposure to ultraviolet A (UVA) radiation trigger the production of ROS. Common visible signs of skin aging, including wrinkles, spots, fine lines, and loss of moisture and elasticity, serve as both indicators and targets for treating skin aging. Anti‐aging peptides have been extensively researched for their potential to prevent skin aging, maintain skin health, and reduce ROS due to their unique properties, including low molecular weight, modifiability, and minimal bioaccumulation. These peptides, known as cosmeceutical peptides, can interact with signaling pathways and receptors that play a crucial role in the skin aging process. Their ability to influence these mechanisms of aging is an important area of ongoing research in the field of skin treatment. Pentapeptide‐3 (Vialox) has the sequence Gly‐Pro‐Arg‐Pro‐Ala and is derived from snake venom. It functions as an antagonist of the acetylcholine receptor, safely blocking the release of sodium ions at the synaptic membrane of muscles. This action prevents muscles from contracting as frequently, leading to muscle relaxation. This article attempts to investigate the potential interactions of Pentapeptide‐3, a synthetic peptide, with…
Read the paper
Related studies
- Chaos and quantum thermalization
- The Dalton quantum chemistry program system
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study
- Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
- Stable adiabatic quantum batteries
- A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.