Exploring the Anthelmintic and Antidiabetic Effects of Rosarin in Preclinical Studies Using Zebrafish and Earthworm Models (Pheretima posthuma)
Abstract
INTRODUCTION: Rhodiola rosea is a traditional medicinal plant that has been found to possess several beneficial properties, including the ability to mitigate cardiac ischemia-reperfusion damage, reduce blood lipid levels, prevent thrombosis, and exhibit antiarrhythmic effects.
OBJECTIVE: This study aims to evaluate the potential of rosarin, a key compound derived from the root of Rhodiola rosea, in treating diabetes mellitus using a zebrafish model and in exhibiting anthelmintic (worm-expelling) activity using the Indian earthworm (Pheretima posthuma).
METHODS: The study design utilizes an experimental approach, incorporating both zebrafish (Danio rerio) and earthworms (Pheretima posthuma) as subjects for testing. The zebrafish were randomly assigned to different experimental groups, including control and treatment groups (e.g., hyperglycemia induction and comparison with Metformin). The zebrafish were studied for a duration of 4 days, during which the glucose concentration was gradually increased. Zebrafish were housed in controlled aquatic environments with daily water changes and hyperglycemia in zebrafish was induced by gradually increasing the glucose concentration, starting with 50 mM for four days while closely monitoring their health and survival. The body weights, blood glucose levels and histopathological studies were noted and compared with the standard drug Metformin. Liver enzymes such as alkaline phosphatase (ALP), Aspartate aminotransferase (AST), and Alanine…
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