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A Systematic Literature Review of Quantum Machine Learning and Its Applications

Yusufcan Sekmen, PARLAK, Bekir

Journal of Computers and Computational Science, 2025

Abstract

Quantum Machine Learning (QML) has become an important research area in recent years due to its potential to overcome the computational bottlenecks faced by classical machine learning methods. In this study, only SCI/SCI-Expanded journal articles published between 2023 and 2025 and accepted as early access for 2026 are considered, and 30 such articles are systematically examined to provide a comprehensive assessment of the current state of QML methods. The reviewed literature covers variational quantum circuits, quantum kernel methods, hybrid quantum–classical models, quantum annealing approaches, federated QML architectures, data encoding strategies, and adversarial robustness analyses. The findings indicate that QML models can exhibit stronger representational capacity and higher generalization performance compared to classical methods, particularly on high-dimensional, noisy, or small sample datasets. Reported results in domains such as healthcare, chemistry, energy systems, cybersecurity, blockchain, and finance reveal the diversity of QML applications and its interdisciplinary potential. Nevertheless, the limited qubit capacity of current NISQ hardware, constraints on circuit depth, and noise-related issues remain fundamental factors that restrict the scalability of QML models. This study synthesizes methodological trends, identifies open research problems, and proposes a directional roadmap for future QML research focused on hardware-aware circuit design, efficient…

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