Ayurvedic perspective of mitochondrial dysfunction and vitiation of Meda Dhatu in obesity (Sthaulya) through insights from quantum biology
Abstract
Obesity, described in Ayurveda as
Sthaulya
, results from
Medodushti
(~vitiation of adipose tissue), which represents a complex metabolic and bioenergetic disorder rather than mere fat accumulation. Ayurvedic texts suggest that
Sthaulya
arises from
Mandagni
(~impaired digestive fire),
Ama
accumulation (~metabolic toxins),
Meda Dhatu Vriddhi
(~increases in fat tissue), and
Srotorodha
(~obstruction of metabolic channels), while modern science associates it with mitochondrial dysfunction, oxidative stress, systemic inflammation, and energy metabolism. This study aims to correlate Ayurvedic pathophysiology and molecular de-regulation with quantum-level bioenergetic mechanisms to provide a framework for understanding obesity. Ayurvedic textual analysis was performed with mitochondrial dysfunction, proteomic, metabolomic, and quantum biology correlates of
Medodushti
and disrupted energy flow. Findings reveal that impaired
Agni
(~digestive/metabolic fire), adipocyte hypertrophy, hypoxia, and inflammation corresponded to mitochondrial stress, incomplete β-oxidation, leptin resistance, and insulin resistance. Quantum-level disturbance in electron transport and energy coherence provides a new concept with
Vata
-mediated energetic disharmony. Correlating Ayurveda with molecular and quantum concepts of obesity as a multi-level bioenergetic disorder may provide insights for designing a personalized and holistic intervention, like dietary modulation and exercise, by guiding future…
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