Metformin use and risk of myeloproliferative neoplasms: a Danish population–based case-control study
Abstract
Key Points • Metformin use was associated with a significant decrease in risk of MPN, with the largest effect observed for the ET and PV subtypes.• A dose-response relationship supported the association with increasing treatment duration, in particular ≥5 years.
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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