Remission of bulimia nervosa observed during administration of liraglutide and metformin: a case report
Abstract
Objective: Bulimia nervosa, an eating disorder characterized by recurrent binging and purging episodes, is frequently associated with depression. Conventional therapy with antidepressants and cognitive behavioral therapy has poor long-term success. Appetite-regulating gut hormones such as glucagon-like peptide 1 (GLP-1) may be implicated in the pathophysiology, and thus, GLP-1 receptor agonists may be an effective therapy. Methods: A 26-year-old patient with polycystic ovary syndrome (PCOS) on chronic metformin therapy, with reactive hypoglycemia, bulimia nervosa, and depression, unresponsive to antidepressants and psychotherapy, was given a trial of liraglutide 1.2 mg daily to control hunger and prolong satiety. Results: The patient reported a more prolonged sensation of satiety after meals and complete resolution of her bulimic behavior within 2 weeks of starting liraglutide. She remains 5 years later with absence of bulimic behavior. She has tried stopping metformin or liraglutide separately but notice...
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