Treatment of paracetamol intoxication: taking into consideration dosage, route of administration, and risk factors
Abstract
- Paracetamol is the drug for which the Dutch Poisons Information Centre (DPIC) receives the most information requests.- The protocol for the treatment of single acute oral paracetamol intoxications is clear, however, ambiguity exists concerning the treatment of intoxications with repeated supratherapeutic doses of paracetamol.- Paracetamol intoxications with liquid preparations, extended-release tablets, exposure routes other than oral, and repeated supratherapeutic ingestions require a tailored approach.- An increased risk of liver damage due to paracetamol intoxication has to be taken into account for patients who consume excessive levels of alcohol, are malnourished or have a pre-existing liver condition.- The decision tree of the DPIC is a helpful tool to swiftly attain a risk assessment and treatment plan for most types of paracetamol intoxication.
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