Effect of Moringa Oleifera Leaf Extract on Paracetamol Induced Liver Damage in Wistar Albino Male Rats
Abstract
Liver disease is a leading cause of global morbidity and mortality, for which virus, toxin and drugs are common risk factors. Paracetamol is a common analgesics and antipyretic drug but at overdose can cause severe hepatotoxicity. Moringa oleifera is a highly nutritious vegetable tree with variety of potential uses which may have hepatoprotective effect. The objective of the study was to observe the effect of Moringa oleifera (Sajna) leaf extract on paracetamol induced liver damage in Wistar albino male rats. This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka, Bangladesh from 1st July 2021 to 30th June 2022. A total number of twenty-four (24) apparently healthy Wistar albino male rats, 90-120 days old, weighing between 200-250gm were taken for this study. After acclimatization for 14 days, they were divided into three groups: Negative control group (Group A), Positive control group (Group B) and Experimental group (Group C). Each of this group was consisted of eight rats. All the rats received basal diet for 28 days. In addition to basal diet Group B and Group C received paracetamol orally (2g/kg/day) for last 3 days (26th to 28th days) of the study period. Again, Group C also received aqueous extract of Moringa oleifera leaf orally (200 mg/kg/day) for 28 days. Then all the rats were sacrificed on 29th day. After sacrifice blood and liver samples were collected. Blood sample was collected from heart. Serum…
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