Postoperative Analgesic Effects of Pre-emptive Intravenous Paracetamol Versus Ibuprofen in Laparoscopic Cholecystectomy: A Randomized, Double-Blind Study
Abstract
Introduction Effective postoperative pain control is essential for enhanced recovery and improved patient satisfaction following laparoscopic cholecystectomy. Pre-emptive administration of non-opioid analgesics, such as intravenous paracetamol and ibuprofen, has been incorporated into multimodal analgesic strategies to reduce postoperative pain and opioid consumption. This study compared the analgesic efficacy and safety of pre-emptive intravenous paracetamol and intravenous ibuprofen in patients undergoing elective laparoscopic cholecystectomy. Objective The primary objective of this study was to compare postoperative pain intensity between pre-emptive intravenous paracetamol and intravenous ibuprofen using the Visual Analogue Scale (VAS) at the end of surgery and at 2, 6, 12, 18, and 24 hours postoperatively. Secondary objectives included comparison of perioperative haemodynamic parameters (heart rate, mean arterial pressure, and peripheral oxygen saturation) and assessment of drug-related adverse effects, including postoperative nausea and vomiting. Methodology This prospective, randomized, double-blind, parallel-group comparative study was conducted in the Department of Anaesthesiology and Critical Care, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, India, between August 2023 and January 2025. Ninety patients aged 18-60 years with American Society of Anesthesiologists (ASA) physical status I or II undergoing elective laparoscopic cholecystectomy under…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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