Bioactivity-guided identification of a quercetin-rich ethyl acetate fraction from Ipomoea pes-tigridis L. conferring robust antioxidant defense and hepatoprotection against paracetamol-induced liver injury
Abstract
The present study evaluated the hepatoprotective potential of Ipomoea pes-tigridis L. whole-plants extracts in paracetamol-induced hepatotoxic rat model. Sequential Soxhlet extraction yielded petroleum ether, ethyl acetate, and methanolic extracts, which were assessed at 200 mg/kg following of acute toxicity confirmation (2000 mg/kg). Paracetamol administration (2 g/kg) significantly elevated lipid peroxidation (TBARS: liver 2.99 ± 0.04 vs. control 1.44 ± 0.02 nmol MDA/g) and reduced antioxidant defences, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH) (p Ipomoea pes-tigridis L. confers significant antioxidant-mediated hepatoprotection against paracetamol-induced liver injury.
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