Influence of glycemic control in sleep status in diabetes mellitus patients type 2 and its related with SNPs of SLC47A2: Intron variant
Abstract
OBJECTIVE: Aim: The relationship between diabetes mellitus (DM) and lifestyle quality become important in diabetes research in last year. The present study aims to study the influence of metformin response in sleep in diabetes mellitus patients type 2.
PATIENTS AND METHODS: Materials and Methods: A cross sectional study was designed to achieve study goal, glycemic parameters included fasting blood glucose (FBG), glycated protein (HbA1c%), insulin (IN), insulin resistance (HOMA-IR) and insulin sensitivity (IS). PCR sequencing was used to detect SLC47A2 intronic variants and its related with glycemic control and sleep status.
RESULTS: Results: Among the study population, about 26.3% achieved well glycemic control, 30% were moderately controlled, and 43.8% were poorly controlled. Sleep quality assessment showed that the majority of participants in all glycemic groups experienced intermediate sleep. The prevalence of insomnia increased with worsening glycemic control, from 4.8% in the well-controlled group to 17.1% in poorly controlled participants, in non- statistically significant (p = 0.722). Biochemical parameters confirmed significant differences in fasting blood glucose and HbA1c across the three glycemic categories (p 0.05), in poorly controlled patients, non-significant opposing trends were observed for insulin and insulin resistance, sociodemographic factors included supplement use, education level, and employment were associated with better sleep among poorly…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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