Comparison of Effectivenness Between Ibuprofen and Paracetamol in the Treatment of Fever in Children Aged 0-18 Years a Systematic Review and Meta-Analysis of Randomized Control Trials
Abstract
Fever is defined as one of the acute adaptive physiological responses to conditions caused by infection, characterized by an increase in body temperature ?38°C. Acetaminophen (paracetamol) and ibuprofen are the only two choices of over-the-counter drugs for the antipyretic class. Acetaminophen (paracetamol) and ibuprofen are the two over-the-counter drug choices, the only antipyretic class most often prescribed to treat fever in children. Acetaminophen (paracetamol) is considered the safest over-the-counter drug to control fever in children, while ibuprofen is a non-steroidal anti-inflammatory drug that works by inhibiting the synthesis of prostaglandin E2 in the anterior hypothalamus thereby reducing the temperature regulation center and can achieve a cooling effect. This made the authors interested in presenting a systematic review to compare the antipyretic profiles of acetaminophen with ibuprofen in the treatment of fever in children aged 0-18 years. Articles were searched through the database from January 2019 - January 2022. Searches were obtained from the PUBMED database. There was no attempt by the authors to specifically search for unpublished articles in English or Indonesian. Free full text or articles that can be downloaded for free (open access) articles with randomized controlled trials. The subjects used were children aged 0-18 years. Based on research results that ibuprofen is more effective than acetaminophen in treating fever in children. This was evidenced…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial
- Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial
- Comparison of the Post-Caesarean Analgesic Effect of Adding Dexmedetomidine to Paracetamol and Ketorolac: A Randomized Clinical Trial
- A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions
- An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients
- Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.