Aspirin, paracetamol (acetaminophen) and caffeine for the treatment of acute migraine attacks: A systemic review and meta‐analysis of randomized placebo‐controlled trials
Abstract
Many migraine patients rely on over‐the‐counter analgesics for the treatment of migraine attacks. Fixed‐dose combinations of aspirin, paracetamol and caffeine (APC) have been used for treating migraine in many countries for a long time. We performed a meta‐analysis for the comparison of APC versus placebo, which has not been done to date.
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Evidence Hub reads this as a randomized trial. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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