Paracetamol, non‐steroidal anti‐inflammatory drugs and glucocorticoids for postoperative pain: A protocol for a systematic review with meta‐analysis and trial sequential analysis
Abstract
Multimodal analgesia is the leading principle for managing postoperative pain. Recent guidelines recommend combinations of paracetamol and a non‐steroidal anti‐inflammatory drug (NSAID) for most surgeries. Glucocorticoids have been used for decades due to their potent anti‐inflammatory and antipyretic properties. Subsequently, glucocorticoids may improve postoperative analgesia. We will perform a systematic review to assess benefits and harms of adding glucocorticoids to paracetamol and NSAIDs. We expect to uncover pros and cons of the addition of glucocorticoid to the basic standard regimen of paracetamol and NSAIDs for postoperative analgesia.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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