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High Prevalence of Metformin-Associated Vitamin B12 Deficiency Among Type 2 Diabetic Patients in Libya: A Cross-Sectional Study

Halima.A. Assoudani, Mayar Abositta, Salsabeel Zarqouni

Arraid Journal of Science and Technology ( AJST), 2026

Abstract

Metformin is a drug regularly used to treat type 2 diabetic patients by controlling blood glucose concentration. It is heavily linked to vitamin B12 deficiency. While this association has been thoroughly studied in Western demographics, Libyan data are lacking. Genetic, dietary, and environmental factors may result in different results than those found in other cohorts.

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.

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