The effect of preemptive intravenous paracetamol-mannitol on postoperative analgesia and quality of recovery in elderly patients undergoing total hip arthroplasty
Abstract
BACKGROUND: Total hip arthroplasty (THA) is a common orthopedic surgery for elderly patients, but it is often associated with severe postoperative pain, leading to increased opioid consumption and delayed recovery. Against the backdrop of the increasing popularity of multimodal analgesia strategies, this study aimed to investigate the effects of preemptive intravenous administration of paracetamol-mannitol injection on postoperative analgesia, inflammatory response, and quality of recovery in elderly patients undergoing THA. METHODS: Sixty-six elderly patients scheduled for elective THA were randomly allocated using a random number table into either the experimental group (Group A, receiving paracetamol-mannitol injection 30 min before surgery) or the control group (Group C, receiving an equal volume of normal saline). All patients received a sufentanil-based patient-controlled intravenous analgesia (PCIA) pump postoperatively. The primary endpoint was the Visual Analog Scale (VAS) score at rest 24 h postoperatively. Secondary endpoints included cumulative 24-hour sufentanil consumption, time to the first analgesic request, number of effective PCIA demands, Brugge-mann Comfort Scale (BCS) scores, incidence of adverse reactions, and changes in serum levels of inflammatory markers (IL-1β, IL-6, TNF-α) and the neuro-stress protein S100β. RESULTS: All 66 enrolled patients completed the study with no dropouts. The baseline characteristics of the two groups were comparable.…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 66 participants or records.
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