Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study
Abstract
Background and aim: Recent studies have demonstrated that hyoscine-n-butylbromide has an antiemetic effect. We aimed to compare the effects of hyoscine-n-butylbromide and ondansetron on postoperative nausea-vomiting (PONV) and pain after laparoscopic cholecystectomy.
Methods: In this randomized study, a total of 134 patients between 18 and 65 years, who underwent laparoscopic cholecystectomy, were divided into two groups, and their demographic data were recorded. After routine monitoring, induction was performed with propofol, fentanyl, and rocuronium, then sevoflurane, and remifentanil were used for maintenance. After gallbladder removal, IV infusion of 1000 mg paracetamol and 1.5 mg/kg tramadol was administered to the patients. Simultaneously, 20 mg hyoscine-n-butylbromide (HBB) in 100 ml saline was administered in Group-HBB, and 4 mg ondansetron infusion in 100 ml saline was administered in Group-O. The patients were followed up in terms of nausea and vomiting, and pain at the postoperative 15th and 30th minutes and at the 3rd, 6th, 12th, and 24th h.
Results: Total PONV rate was found to be 38%. In the 24-h follow-up of the patients, PONV was observed at least once in 26 (39.4%) patients in Group-HBB, and in 25 (36.7%) patients in Group-O, and there was no difference between the two groups. Scores of PONV, antiemetic use rates, VAS scores, and analgesic use rates were similar during the 24-h follow-up.
Conclusion: The effects of hyoscine-n-butylbromide and ondansetron on…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 134 participants or records.
Read the paper
Related studies
- Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial
- Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial
- Comparison of the Post-Caesarean Analgesic Effect of Adding Dexmedetomidine to Paracetamol and Ketorolac: A Randomized Clinical Trial
- A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions
- An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients
- Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.