Effects of acute GLP-1 analogue infusion on the glycemic and neurohormonal responses to meal test in non- hypoglycemic subjects after gastric bypass
Abstract
PURPOSE: The aim of this study was to assess the effects of acute Glucagon-like peptide-1 (GLP-1) receptor agonist administration on metabolic and endocrine responses to a standardized meal test in individuals who have undergone Roux-en-Y gastric bypass surgery (RYGB), and thus to uncover mechanisms that might be important in post-bariatric hypoglycemia. METHODS: In a single-center, randomized crossover study, 10 patients without diabetes underwent two standardized high-carbohydrate meal tests with either saline (SAL) or exenatide (EXE) infusion, one year after RYGB. We assessed glucose, insulin, c-peptide, ACTH, cortisol, GH, adrenalin, noradrenalin, dopamine, glucagon, active GLP-1 and GIP. Gastric emptying rate was estimated with repeated paracetamol measurements. Heart rate variability was recorded as a marker of sympathetic nervous system activity. RESULTS: Postprandial glucose levels dropped below baseline levels in all subjects. Cortisol levels were higher during EXE infusion. As expected, insulin and c-peptide levels were higher with EXE. No other significant differences were observed in the measured hormones. EXE did not affect gastric emptying rate. HRV showed a decreased RR-interval during EXE infusion. CONCLUSION: During a meal test, acute exenatide infusion led to elevated cortisol levels but did not protect against post-prandial drops in glucose levels. Taken together with previous research, this implicates that alleviation of post-prandial hypoglycemia after…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 10 participants or records.
Read the paper
Related studies
- Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial
- Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial
- Comparison of the Post-Caesarean Analgesic Effect of Adding Dexmedetomidine to Paracetamol and Ketorolac: A Randomized Clinical Trial
- A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions
- An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients
- Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.