Effect of a subanesthetic dose of propofol on emergence agitation in adults undergoing rhinoplasty: A prospective randomized controlled trial
Abstract
Background: Emergence agitation (EA) following rhinoplasty can jeopardize surgical outcomes through increased bleeding and hematoma formation. Data on the efficacy of subanesthetic propofol for EA prevention in adults remain limited compared to pediatric populations. This study evaluated the effects of a single subanesthetic dose of propofol administered prior to extubation on the incidence of EA, recovery profile, and patient satisfaction in adult rhinoplasty patients.
Methods: In this prospective, randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov: https://clinicaltrials.gov/show/NCT07276633), 80 adult patients (American Society of Anesthesiologists I-II) undergoing elective rhinoplasty were randomly allocated (1:1) to receive either intravenous propofol 0.5 mg/kg (Group P, n = 40) or 0.9% saline (Group S, n = 40) 10 minutes before the anticipated end of surgery. The primary endpoint was the incidence of EA (defined as a maximum Richmond Agitation-Sedation Scale score ≥ +1). Secondary endpoints included recovery time, patient satisfaction (3-point Likert scale), and adverse events.
Results: The incidence of EA was significantly lower in Group P compared to Group S (60.0% vs 92.5%; relative risk = 0.65, 95% confidence interval: 0.50-0.85; P < .001). Although the mean recovery time was significantly prolonged in Group P (10.0 ± 1.1 minute vs 5.5 ± 1.5 minutes; mean difference = 4.5 minutes, 95% confidence interval: 3.92-5.08; P < .001), patient…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 80 participants or records.
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