Oral Paracetamol versus Oral Paracetamol with Codeine as Intrapartum Analgesic in the First Stage of Labor: Randomized Controlled Trial
Abstract
Labor pain includes components that differ completely from pain in general. It is the result of natural events and has a special meaning, leading in most cases to something extremely positive, the birth of a healthy child. Labor is a painful condition, considered to be one of the most intense and stressful experiences especially for nulliparous women. Although studies have found significant rise in pain threshold during labor. It is nonetheless an important goal to provide safe and effective methods of analgesia for women in a pain in order, amongst other reasons, to obtain her maximum cooperation.
The aim of this study is to evaluate the efficacy and adverse effects of oral paracetamol (500mg) during the active phase of labor compared with oral solpadeine (paracetamol 500mg with codeine 8mg) as a method for intrapartum analgesia.
This study double blinded randomized controlled trial was conducted on 220 low-risk gravid women have labor pain in first stage of labor and need analgesia comparing the effect of administration of oral paracetamol (500mg) and oral paracetamol 500mg with codeine (8mg) (solpadeine capsule) on managing of pain during active phase of labor. Study setting: The current study was conducted at Ain Shams University Maternity Hospital for about 6 months from February to August 2017.
As recorded by the VAS score, there was significant pain reduction at 1, 2, 3 and 4 hours in both groups (P = 0.001). The reduction in pain was significantly greater in the…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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