Investigating a Technique for Forming Paracetamol-Surfactant Micelles
Abstract
Micelles are spheres of molecules that enhance the solubility and stability of low-solubility drugs by increasing their interactions with water. These structures possess hydrophobic (water repelling) cores and hydrophilic (water attracting) exteriors, making them suitable carriers for such drugs. They form from amphiphilic substances, which contain both hydrophobic and hydrophilic regions. Sodium lauryl sulfate (SLS) is an example of an amphiphilic substance.This investigation demonstrates the feasibility of encapsulating paracetamol, a test drug, in SLS micelles in solution. Standard laboratory apparatus was used for synthesis, and Nuclear Magnetic Resonance (NMR), an analytical technique, was utilized for analysis. The findings confirmed successful micelle formation using the synthetic technique applied. This supports the potential of micelle encapsulation as a method to enhance the solubility of pharmaceuticals, thereby improving their absorption by the body.
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