Formulation and Evaluation of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique
Abstract
The goal of this study was to formulate Paracetamol loaded Eudragit S100 nanoparticles by salting out technique. Eudragit S100 was used as a polymer. Paracetamol and polymer were dissolved in ethanol at various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation with drug content of 82.24% and entrapment efficiency was found to be 97.87%. Loading capacity was found to be more for 1:3 formulation. Sodium.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and ethanol were used as solvent.
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