Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial
Abstract
Abstract Background: Pain control after every surgery, especially cesarean is very important, and physicians are striving to discover pain control methods using the least amount of opioid. Paracetamol is a non-opioid analgesic with few complications. The present study was aimed to investigate the analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain. Methods: This randomized double-blind clinical trial was conducted on 240 pregnant women under spinal anesthesia who were candidate for elective cesarean. The patients’ weight, height, age and body mass index (BMI) were recorded, and patients were randomly divided into two equal groups (n=120). In the first group, 10 mg/kg paracetamol in 100cc normal saline (paracetamol group) and in the second group 100cc normal saline (control group) administered 15 minutes before surgery intravenously. Blood pressure, pulse rate, chills and nausea were recorded during and 1 hour after surgery, and pain visual analogue scale (VAS) and need for additional analgesic were recorded 1, 2, 4, 6, 12 and 24 hours after surgery. Results : The mean scores of pain were significantly lower in paracetamol group (4.01±2.22) than control group 6 hours (4.83±2.35) (p=0.008) and 24 hours (2.26±1.85 and 2.67±1.80 respectably) (p=0.038) after surgery. Mean meperidine consumed was lower in paracetamol group than control group but not significantly. No significant difference was found between the two groups in frequency…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 240 participants or records.
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