Drug-induced enterocolitis syndrome with paracetamol (acetaminophen) in a 12-month-old-old boy
Abstract
Drug-induced enterocolitis syndrome with paracetamol (acetaminophen) in a 12-month-old-old boy B.Pascalab, B.Evrardac, E.Merlinbc, C.Egronb, B.Bonnetac, E.Michaudba Service d’immunologie, hôpital Gabriel Montpied, Clermont-ferrand, Franceb Service de pédiatrie générale, hôpital Estaing, Clermont-ferrand, Francec Université Clermont Auvergne, Clermont ferrand, FranceTo the Editor,Drug-induced enterocolitis syndrome (DIES) is a new clinical presentation similar to food protein-induced enterocolitis syndrome (FPIES). It was described for the first time in 2014 by Novembre et al.(1). More and more cases have been described since and clinical diagnostic criteria have recently been proposed. (2)A 12-month-old boy was referred to our Pediatric Allergy Unit for a suspected drug hypersensitivity. At age 10 months, he was admitted to the pediatric emergency room for vomiting and fever, previously treated with two intake of intrarectal paracetamol (15 mg/kg every 6 hours), the last one 4 hours before admission. He had no previous history (and no allergic history). During the initial examination, we observed asthenia, paleness, no fever (after antipyretics) and tachycardia, followed by four episodes of mucus vomiting without diarrhea. An occlusive syndrome was suspected. Given the hemodynamic disorders, continued fluid resuscitation was performed. Blood tests showed an isolated hyperleukocytosis with neutrophils (11.08 G/L). Eosinophils (0.210 G/L), lymphoid cells (7.25 G/L), the…
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