Preparation and Evaluation on Paracetamol Tablets Using Goatskin Gelatin as a New Binder
Abstract
Abstract Halal gelatin extracted from goatskin could be used as a new excipient in pharmaceutical dosage forms. This study was to determine the potency of gelatin extracted from goatskin as a binder on paracetamol tablets using wet granulation process with 2, 3 and 4% concentration ranges. As a comparison, tablets were formulated using bovine gelatin at the same concentration level. The results showed that weight variation, thickness uniformity and hardness value have met the requirements. Here, the paracetamol tablets using goatskin gelatin as a binder had better friability value, faster disintegration time and easier dissolution than the comparison (p < 0.05). Comparative test result showed increasing the concentration of gelatine caused the hardness value to go up, the disintegration time to take longer, and the tablet friability value to decrease (p < 0.05). The best tablets were produced with the 3% concentration of goatskin gelatine with the following evaluation results: the hardness value of 15.07 ± 0.67 Kp, the disintegration time of 3.71 ± 1.00 minutes and the friability value of 0.62% ± 0.89 respectively. The concentration of paracetamol in the 30th-minute dissolution test was equal to 99.78 ± 0.94%. The goatskin gelatin was very promising as a good binder using the wet granulation process.
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