Evaluation of Oral Acetaminophen on Tear Production and Intraocular Pressure in Healthy Dogs
Abstract
Objective: To assess the effects of a therapeutic dose of oral acetaminophen on Schirmer tear test I (STT-1) and intraocular pressure (IOP) in healthy dogs.
Animals studied: Fourteen healthy adult beagle dogs.
Procedures: All animals underwent a physical and ophthalmic examination, hematology, and plasma biochemistry prior to treatment. Oral acetaminophen at 30 mg/kg every 12 h for 5 days was administered. STT-1 and IOP were measured in both eyes before drug administration. Ocular adverse effects were assessed using a semiquantitative preclinical ocular toxicology scoring system. All measurements were performed by the same investigator under controlled environmental conditions. At the end time point, follow-up physical and ophthalmic examinations and blood workup were conducted.
Results: STT-1 remained stable throughout the study, with no significant differences between time points (p = 0.665) or overall trend over time (p = 0.356). IOP showed no consistent temporal trend (p = 0.602), although significant differences were observed between specific time points (p = 0.003). IOP at 24 h was higher than at 12 h (p = 0.031) and 60 h (p = 0.009), and at 0 h compared to 60 h (p = 0.043); however, these differences were transient and clinically irrelevant (1-2 mmHg). Mild conjunctival hyperaemia and fluorescein staining uptake were observed in 3/28 eyes, although these were mild and resolved spontaneously without treatment. No systemic adverse effects were detected.
Conclusions:…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial
- Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial
- Comparison of the Post-Caesarean Analgesic Effect of Adding Dexmedetomidine to Paracetamol and Ketorolac: A Randomized Clinical Trial
- A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions
- An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients
- Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.