PALLIHIP-study: Spinal Phenol IN Glycerol (SPING-block) in palliative, frail, older adults with a hip fracture: a study protocol
Abstract
Background: In the Netherlands, approximately 20,000 older adults sustain a hip fracture every year. Most of these patients are frail, institutionalised, have limited postoperative mobility and a high mortality rate. When surgery is not feasible or preferred, optimizing quality of life and effective pain management becomes paramount. However, current analgesic strategies often fail to provide sustained relief and timely discharge. Timely discharge is essential to prevent hospital-related complications in frail patients. The Spinal Phenol IN Glycerol (SPING) block, a novel intrathecal neurolytic technique adapted from spinal anaesthesia, has been developed as an innovative approach for palliative pain treatment in this patient population. The PALLIHIP study aims to evaluate the effects of the SPING block on pain and quality of life in frail, institutionalised older adults with hip fractures.
Methods: PALLIHIP is a prospective multicentre cohort study that will be conducted in 19 Dutch hospitals. PALLIHIP will aim to enroll 210 patients. The primary objective is to evaluate the impact on pain and quality of life, assessed at admission, 24 h, one week, six weeks, and three months after treatment with SPING. Secondary outcomes include complications, mobility level, care dependency, caregiver burden, quality of dying, survival, and patient and caregiver satisfaction. Patient characteristics associated with treatment success will be explored. Healthcare and societal costs will be…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 20,000 participants or records.
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