Does the pre-emptive administration of paracetamol or ibuprofen reduce trans and postoperative pain in primary molar extraction? A randomized placebo-controlled clinical trial
Abstract
BACKGROUND
There is no consensus whether the pre-emptive administration of analgesics reduces trans and postoperative pain in primary molar extraction.
AIM
Investigate whether the pre-emptive administration of ibuprofen and paracetamol reduces trans and postoperative pain on primary molars extraction compared to placebo.
DESIGN
A parallel, placebo-controlled, triple-blind, randomized clinical trial was conducted. Forty-eight children who needed primary molar tooth extraction were selected and treated under local anesthesia and pre-emptive administration of placebo or analgesics. Self-reported pain was evaluated during the anesthesia, extraction and 2, 6 and 24 hours of postoperative period, using a Visual Analogue Scale (VAS). Children's baseline anxiety, behavior during the procedure, parents' anxiety and postoperative analgesia were also assessed. Data analysis included descriptive statistics and multiple linear regression.
RESULTS
No association was found between the use of pre-emptive analgesic and lower scores of trans and postoperative pain compared to placebo. Children who presented negative behavior reported greater pain during anesthesia (p=0.04) regardless of preemptive analgesia group. Children from the placebo group were more likely to need postoperative analgesia at 2 hours of follow-up (p=0.03).
CONCLUSION
The pre-emptive administration of analgesics did not significantly reduce trans and postoperative pain in children after primary molars extraction.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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